Acne Infections

2007-12-13 Word Count: 510 Category: Acne

Acne starts during puberty when your body signals your sebum glands to secrete an oily substance that when on the surface of the skin it soothes it and shields your skin from infection by microbes that thrive there permanently. If sebum does not outflow freely through the sebum canals to the exterior it produces multiple skin injuries that initiate an inflammatory reaction and the sebum trapped there becomes a rich feeding ground for the growth of microbes.
The skin is confronted with heavy demands when one of these infections occur. Areas with recurrent acne infections due to moderate or severe acne frequently develop deficiencies of essential ingredients, impairing the skin's ability to defend itself and heal effectively.
Acne infections destroy collagen and elastin fibers, sever the microvascular network and harm and kill cells. When healing occurs, normally after a long time if a proper acne treatment has not be applied, a scar is left in the skin. The healthy functional tissue (skin) is replaced by connective tissue (scar).
Organic Ingredient Known to Treat Acne
Nowadays, antibiotics like penicillin are not powerful as they were before to deal with bacteria. What really occurs is that the bacteria, having a high rate of mutation, ends up changing one or more of its enzymes that are used to destroy the link between a target protein and the antibiotic. As a result, the antibiotic does not work.
But this system fails when the attacker punches holes in the cell membrane, as peptide antibiotics do. To defend itself, the bacterium would have to modify the entire composition of the cell membrane. And to change the composition of a membrane would mean modifying many of the enzymes that are responsible for making the complex membrane in the first place.
Peptide antibiotics respond within minutes helping treat acne instantly. Part of the reason for this quick response is how the peptide acts on the cell membrane. But to kill a cell, the peptide must also quickly find the bacterial membrane. How does this occur? The answer lies in the structure of the cellular membrane.
The plasma membrane of eukaryotic cells is much different than the membrane of a prokaryotic cell. Eukaryotic cell membranes are constructed of a phospholipid bilayer and cholesterol. Consequently, these membranes have a low negative electrical charge. On the other hand, a bacterial membrane is made up of fats and sugars. This difference in composition means that bacteria have a high negative electrical charge that promptly attracts the peptide antibiotics.
Peptide antibiotics are efficient. In a clinical trial for the treatment of meningitis, a sickness that affects 3,000 children a year, a peptide antibiotic not only destroyed the bacterium which mades the toxin, but it also bound to the toxin avoiding the harm the endotoxin causes. But bringing a drug to clinical trial is time consuming and expensive. It takes $300 million to bring a drug to market. This cost includes every thing from finding, identification, synthesis and clinical trials. This process may also take 10 or more years to accomplish.

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